The news network reported that he committed suicide in his hotel room in Paris, France, while recording an episode for his TV series "Anthony Bourdain: Parts Unknown," which was in its 11th season.
"It is with extraordinary sadness we can confirm the death of our friend and colleague, Anthony Bourdain," a statement from CNN said. "His love of great adventure, new friends, fine food and drink and the remarkable stories of the world made him a unique storyteller. His talents never ceased to amaze us and we will miss him very much.
"Our thoughts and prayers are with his daughter and family at this incredibly difficult time."
People took to Twitter to react to the news.
His death comes three days after designer Kate Spade died in another apparent suicide.Police say a housekeeper found her unresponsive, CBS reported, and correspondent Jericka Duncan reported that she left a suicide note for her 13-year-old daughter.
Suicide rates have risen in all states except Nevada between 1999 and 2016, according to a Thursday report from the Centers for Disease Control and Prevention. Suicide is the 10th biggest cause of death in the U.S, and the most frequent method was with a gun.
You can call the National Suicide Prevention Lifeline at 1-800-273-8255 if you or someone you know is struggling with suicidal thoughts.