Greg Cote

NFL Thursday night: Playoff stakes high as 49ers, Titans open Week 16. Upset in store? Our pick

Tennessee Titans defensive tackle Jeffery Simmons (98) celebrates after sacking Los Angeles Rams quarterback Matthew Stafford (9) during the first quarter at SoFI Stadium Sunday, Nov. 7, 2021 in Inglewood, Calif. Titans Rams 038
Tennessee Titans defensive tackle Jeffery Simmons (98) celebrates after sacking Los Angeles Rams quarterback Matthew Stafford (9) during the first quarter at SoFI Stadium Sunday, Nov. 7, 2021 in Inglewood, Calif. Titans Rams 038 Tennessean.com / USA Today Network

NFL WEEK 16

GREG COTE’S THURSDAY PICK

49ERS (8-6) at TITANS (9-5)

Line: SF by 3 1/2.

Cote’s pick: TEN, 23-20.

TV: 8:20 p.m. Thursday, NFL.

Major playoff bearing to open Week 16 -- wait, didn’t Week 15 just end? -- as Tennessee fights to hang onto its dwindling division lead and San Fran climbs into wild-card contention with three games to play. Makes for an interesting finale to the season’s Thursday night schedule. I get why the 49ers are favored. Recent form is the answer. Niners are on a 5-1 run (three of those wins by 18 or more points, while Titans have dropped three of past four. Turnovers have killed Tennessee including in last week’s loss to Pittsburgh; Titans have 13 giveaways in past three defeats. And an exposed Ryan Tannehill has morphed back into the average QB Miami knew, not the one made to look great before Derrick Henry got hurt. So why am I calling an upset here? Tennessee is stout at home (5-2) and SF is due an off game. More than that, while Niners’ ground game has led its surge, Titans present the NFL’s No. 2-ranked run defense and should be able to neutralize Frans’ strength. I’m banking on home field and run D to carry my pick. The variable is turnovers. All I want for Christmas is the Titans to take care of the ball. Please?

[Note: Betting line courtesy Caesars Sportsbook as of Wednesday afternoon. Picks for remainder of Week 16 games will appear online Thursday afternoon and in print Friday].

This story was originally published December 22, 2021 at 2:01 PM.

Greg Cote
Miami Herald
Greg Cote is a Miami Herald sports columnist who in 2025 won a first-place Green Eyeshade award in Sports Commentary and has finished top 10 in column writing by the Associated Press Sports Editors on multiple occasions. Greg also hosts The Greg Cote Show podcast and appears regularly on The Dan LeBatard Show With Stugotz.
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