After losing in Seattle on Sunday, things don't get any easier for the Dolphins in Week 2.
Up next for the Dolphins: A trip to Foxborough and a date with the New England Patriots.
In case you missed it, the Patriots became the only AFC East team to win their opener late Sunday night as they beat the host Cardinals 23-21 in Glendale.
The Patriots beat one of the top NFC teams minus starting quarterback Tom Brady as he served the first of a four-game suspension for his role in 'Deflategate' as well as the hamstrung Rob Gronkowski.
Jimmy Garoppolo, filling in for Brady for these first four games, made his first NFL start and completed 24 of 33 passes for 264 yards and a touchdown.
The Patriots did need some help to beat Arizona, however, as Chandler Catanzaro missed a 47-yard kick with 41 seconds remaining.
“We still had a chance to win the game, as poorly as we played,” coach Bruce Arians told reporters.
New England's next three games minus Brady will come in the friendly confines of Gillette Stadium with Miami, Houston and Buffalo coming for a visit.
So it looks like New England may be 4-0 by the time Brady returns for the Browns (make that 5-0) on Oct. 5.
The Dolphins have beaten the Patriots at least once a season since 2013 and took out New England in last year's season finale costing the Pats home field advantage throughout the playoffs and thereby sending them to Denver for the AFC championship.
Miami's past four victories over the Patriots, however, have come at home.
The Dolphins haven't won at Gillette since Ronnie Brown’s Wildcat game on Sept. 21, 2008 — a run of seven consecutive losses.
Since Miami’s blowout win in 2008, the Patriots are 11-4 against the Dolphins.
Miami lost its opener 12-10 in Seattle on Sunday.
Things do get easier in Week 3 as the Dolphins play their home opener on Sept. 25 against the Browns (0-1) at Hard Rock Stadium.