A week after clinching its first postseason berth since 2008, Palmetto overcame a slow start to beat Ferguson 28-15 on Thursday afternoon at Tropical Park.
Quarterback Hugh Lowson threw three touchdown passes, including an early 76-yarder to De’Andre Thompson that tied the score at 7.
Lowson ran for a touchdown later in the quarter to put Palmetto (8-1) ahead for good.
Ferguson, which finished a much more competitive season with a 3-6 record a year after going winless, had two first-half interceptions by Ivan Ramirez and took an early 7-0 lead on a 10-yard touchdown pass from Mike Lopez to Christian Cabral.
The Panthers scored 28 unanswered points following that score.
Palmetto will play at Belen Jesuit next Friday at 3 p.m. in a Region 4-8A quarterfinal.
“We had a huge, crazy game against Killian last week [to clinch a playoff spot] and that made this a tough week,” Palmetto coach Mike Manasco said. “And Ferguson didn’t make it easy on us either. They’re well coached and have some tough kids.”