Global charity Best Buddies cuts ties with Kevin Spacey

Kevin Spacey is not only persona non grata in Hollywood these days, but in charity circles as well.

The actor is in an Arizona rehab facility for sex addiction after a series of sexual misconduct allegations surfaced, beginning with actor Anthony Rapp’s claim last month that Spacey tried to seduce him at age 14.

Spacey, 58, was soon axed from his Netflix hit “House of Cards,” and he was replaced last week by Christopher Plummer in the upcoming Ridley Scott film, “All the Money in the World.”

Now, the scandal is affecting even more of Spacey’s life. His gig as global ambassador for Best Buddies International, the Miami nonprofit, is kaput.

“Here at Best Buddies, we pride ourselves on a culture of respect, inclusion, equality and empowerment,” said a statement from Anthony K. Shriver, founder, chairman & CEO at Best Buddies International, a nonprofit that works with developmentally challenged young people. “In light of the recent reports, we will be ending our relationship with Kevin Spacey as a Best Buddies Global Ambassador.”

The severing of ties with the “American Beauty” star could prove costly. Best Buddies paid Spacey’s personal charity a one-time grant of $200,000 in 2015, according to a report in the Boston Globe.

Shriver is the nephew of John F. Kennedy, the late U.S. president, and the son of Eunice Kennedy Shriver, JFK’s sister. With his longtime Massachusetts connections, Shriver and Best Buddies have cultivated New England Patriots star quarterback Tom Brady.

Best Buddies is holding its annual gala Friday night at the Ice Palace Studios in Wynwood. Iggy Azalea will be the musical guest.