Baltimore Orioles (71-52) at Chicago White Sox (59-66), 8:10 p.m. (ET)

08/18/2014 10:43 AM

08/19/2014 10:49 AM

( - After taking the opener behind Nick Markakis' bat and glove, the Baltimore Orioles try to secure a series victory on Tuesday night in the second contest of a three-game set with the Chicago White Sox.

Markakis played a key role in last night's 8-2 win, robbing Conor Gillaspie of a potential go-ahead homer in the seventh and then hitting a two-run homer in the eighth as part of a five-run frame.

Avisail Garcia's two-run single to right scored Alejandro De Aza and Alexei Ramirez in the seventh to get the White Sox within 3-2. Gillaspie was up next and sent a fly ball to right field. Markakis reached his glove over the wall to take away the home run.

"That's the best play of the year," said Baltimore starter Bud Norris, who yielded two runs and three hits over seven innings.

Jonathan Schoop had a three-run double in the eighth for the O's. Markakis went 3-for-5 with two runs scored and Steve Pearce also had three hits and an RBI. J.J. Hardy and Nelson Cruz clubbed solo homers for the AL East leaders, who opened up a 7 1/2-game advantage on the second-place New York Yankees.

Chris Sale yielded eight hits and three runs, but he did have eight strikeouts in losing his second straight decision. Sale threw 121 pitches in the opener of this three-game set.

"He wasn't necessarily on tonight, but they worked him over pretty good," White Sox manager Robin Ventura said.

The Orioles won two of three versus the White Sox at home from June 23-25 and have claimed six of the past eight meetings overall.

Chris Tillman tries to avoid his first loss since July 12 when he starts tonight for the Baltimore. The Orioles have won each of his past four outings, with Tillman 2-0 in that span.

Following back-to-back wins, Tillman did not factor into a 5-3 decision over the New York Yankees on Wednesday. The 26-year-old righty gave up two runs over seven innings.

Tillman is 9-5 with a 3.68 earned run average on the season and 2-1 in his career versus the White Sox with a 4.30 ERA.

Jose Quintana hopes to avoid a third straight losing start for the White Sox and is coming off a 7-1 setback to San Francisco on Wednesday.

The left-hander did not allow a run over the first six innings of that outing, but ended up yielding four while recording two outings in the seventh. He fell to 6-9 with a 3.14 ERA on the year.

Quintana, 25, is 1-2 in his career versus Baltimore with a 3.28 ERA.

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