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Several substances inhibiting so-called HDAC enzymes have been studied in trials searching for new anti-cancer drugs in recent years. “Trials have shown that HDAC inhibitors are very effective in arresting growth of cultured cancer cells. But apart from a very rare type of lymphoma, these drugs unfortunately do not clinically [...]
Researchers at Johns Hopkins have succeeded in teaching computers how to identify commonalities in DNA sequences known to regulate gene activity, and to then use those commonalities to predict otherÂ regulatory regions throughout theÂ genome. The tool is expected to help scientists better understand disease risk and cell development.
The work was reported [...]
In a culture that emphasizes productivity, the value of a supportive mentor can be overlooked. Mentorship, however, is the backbone of a strong research community. That was the message of the Society of Research Fellows at Scripps Florida that recently awarded its first Mentorship Award to Professor John Cleveland.
â€śWe wanted [...]
Edith Sanford Breast Cancer Foundation and the Scripps Research Institute Partner to Advance Genomic Breast Cancer Research
TheÂ Edith Sanford Breast Cancer Foundation andÂ The Scripps Research Institute (TSRI) recently announced a dynamic, interdisciplinary collaboration that will lay the groundwork for significant advancements in personalized breast cancer treatment and care.
Edith Sanford Breast Cancer Research will leverage TSRIâ€™s expertise in genomic sequencing as it embarks on a proof-of-concept study to [...]
Researchers have unlocked the complex cellular mechanics that instruct specific brain cells to continue to divide.Â This discovery overcomes a significant technical hurdle to potential human stem cell therapies; ensuring that an abundant supply of cells is available to study and ultimately treat people with diseases. Pleiotrophin Suppression of Receptor [...]
It looks like Mother Nature was wasting her time with a multimillion-year process to produce crude oil. Michigan Engineering researchers can “pressure-cook” algae for as little as a minute and transform an unprecedented 65 percent of the green slime into biocrude.
“We’re trying to mimic the process in nature that forms [...]
Scientists have discovered that breaking a biological signaling system in an embryo allows them to change the destiny of a cell. The findings could lead to new ways of making replacement organs.
The discovery was made in the laboratory of Joel H. Rothman, a professor in the Department of Molecular, Cellular, [...]
Stem cells are a valuable resource for medical and biological research, but are difficult to study due to ethical and societal barriers. However, genetically manipulated cells from adults may provide a path to study stem cells that avoid any ethical concerns. Â Generation of Human Induced Pluripotent Stem Cells from [...]
Whitehead Institute researchers report that common assumptions employed in the generation and interpretation of data from global gene expression analyses can lead to seriously flawed conclusions about gene activity and cell behavior in a wide range of current biological research. Revisiting Global Gene Expression Analysis is published in Cell.
The ALS Recovery Fund, a steadfast ally in the fight against amyotrophic lateral sclerosis, commonly known as Lou Gehrigâ€™s disease, has pledged another $1 million to the Department of Neurology for its continued ALS research and patient support.
The gift will expand upon the Miller Schoolâ€™s existing programs and provide additional [...]