PainCare to Voluntarily Delist from American Stock Exchange

By PainCare Holdings, Inc.

    -- The Company has failed to timely file periodic reports with the
       Securities and Exchange Commission (the "SEC"), in violation of
       Sections 134 and 1101 of the AMEX Company Guide.
    -- The Company has failed to comply with Sections 1003(a)(i); Section
       1003(a)(ii) and Section 1003(a)(iii) as well as Section 1003(a)(iv) of
       the AMEX Company Guide.

For a recap of the previously released details regarding the notice from the American Stock Exchange please review the Press Release dated April 22, 2008. PainCare currently intends that the delisting will be effective on or about Thursday, May 29, 2008. After withdrawal of its common stock from listing on the AMEX, the Company expects that the shares will be quoted on the OTC Pink Sheets. PainCare will announce its new ticker symbol at that time.

About PainCare Holdings, Inc.

Headquartered in Orlando, Florida, PainCare Holdings, Inc. is a provider of pain-focused medical and surgical solutions and services. Through its proprietary network of acquired or managed physician practices, and in partnership with independent physician practices and medical institutions throughout the United States and Canada, PainCare is committed to utilizing the most advanced science and technologies to diagnose and treat pain stemming from neurological and musculoskeletal conditions and disorders. Through its subsidiary Integrated Pain Solutions (IPS), the Company is engaged in pioneering the nation's first managed services organization that offers a multi-disciplinary healthcare network focused on the treatment of pain. For more information on PainCare Holdings, please visit www.paincareholdings.com.

This press release contains forward-looking statements that may be subject to various risks and uncertainties. Such forward-looking statements are made pursuant to the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995 and are made based on management's current expectations or beliefs as well as assumptions made by, and information currently available to, management. These forward-looking statements, which may include statements regarding our future financial performance or results of operations, including expected revenue growth, cash flow growth, future expenses, future operating margins and other future or expected performance, are subject to the following risks: the acquisition of businesses or the launch of new lines of business, which could increase operating expenses and dilute operating margins; the inability to attract new patients by our owned practices, the managed practices and the limited management practice; increased competition, which could lead to negative pressure on our pricing and the need for increased marketing; the inability to maintain, establish or renew relationships with physician practices, whether due to competition or other factors; the inability to comply with regulatory requirements governing our owned practices, the managed practices and the limited management practices; that projected operating efficiencies will not be achieved due to implementation difficulties or contractual spending commitments that cannot be reduced; and to the general risks associated with our businesses.

In addition to the risks and uncertainties discussed above you can find additional information concerning risks and uncertainties that would cause actual results to differ materially from those projected or suggested in the forward-looking statements in the reports that we have filed with the Securities and Exchange Commission. The forward-looking statements contained in this press release represent our judgment as of the date of this release and you should not unduly rely on such statements. Unless otherwise required by law, we undertake no obligation to publicly update or revise any forward- looking statements, whether as a result of new information, future events or otherwise after the date of this press release. In light of these risks and uncertainties, the forward-looking events and circumstances discussed in the filing may not occur, and actual results could differ materially from those anticipated or implied in the forward-looking statements.

    FOR MORE INFORMATION, PLEASE CONTACT:
    Investor/Shareholder Relations
    Dodi Handy, President and CEO
    Elite Financial Communications Group, LLC
    at 407-585-1080 or via email at prz@efcg.net

SOURCE PainCare Holdings, Inc.