The Dodgers, though, got the best of the Cardinals the last time these clubs met in October, sweeping them in the 2009 NLDS.
Combined, the two teams have accounted for 17 World Series titles. While the Cards last won in 2011, the Dodgers are trying to get back to that round for the first time since winning it all in 1988.
"It's going to be a blast," Cardinals third baseman David Freese said. "It's going to be fun. St. Louis and L.A. going at it. Obviously, they're a great team. ... It's going to be huge. It's going to be a lot of fun."
St. Louis finds itself back in the NLCS for the third straight year after a terrific regular season campaign that saw the club win an NL-best 97 games. The Cardinals, though, needed all five games to get past the upstart Pittsburgh Pirates in the NLDS.
After falling behind 2-1 in that set, the Cards rallied back to win the next two backed by a pair of tremendous pitching performances. After rookie Michael Wacha flirted with a no-hitter to win Game 4, ace Adam Wainwright put the hammer down in the decisive fifth game with a little help from another postseason hero.
Freese, the 2011 World Series MVP, set the tone with a two-run home run, while Wainwright scattered eight singles and struck out six in a complete-game win.
"To pitch a game like that is one of the highlights of my baseball life, no doubt," Wainwright said. "These are the kind of moments starting pitchers live for."
Wainwright, who led the NL with 19 wins, won't be available until Game 3.
St. Louis manager Mike Matheny has a decision to make as it pertains to Game 1 starter on Friday. Righties Lance Lynn, Joe Kelly and even Shelby Miller, who did not pitch in the NLDS, are all a consideration.
There are no questions as to who will be starting Game 2 and that will be Wacha, who has nearly thrown a no-hitter each of the last two times he has taken the hill.
The team's first pick in the 2012 draft, Wacha saved the Cardinals season in Game 4 of the NLDS in Pittsburgh, as he took a no-hitter into the eighth in a stellar 7 1/3-inning, nine-strikeout performance. He had come within an out of no-hitting Washington in his final regular season start.
"We did a lot of gushing about him before we even got him out there today, and I think everybody sees why," Matheny said after his NLDS outing. "I don't know if you can put a kid in a tougher spot. He came out and just made pitches all day long. He's just got a knack of getting up there and (being) very business- like getting the job done."
Carlos Beltran added to his postseason legacy by driving in six runs in the five-game set. Amazingly he only hit .222, but his .944 OPS in this series was his second lowest OPS in a playoff series.
One of the top postseason performers of all time, Beltran hit his 16th postseason home run in Game 3 and surpassed Babe Ruth for the eighth-most in baseball history. Beltran's 1.247 OPS in the postseason is the highest in any player's career.
Pittsburgh walked Beltran twice to lead off an inning in the series and the second time the Cards made it pay, as Matt Holliday's two-run home run was the difference in St. Louis' Game 4 win.
"There's plenty to think about beyond Carlos," Matheny said.
In addition to being the best defensive catcher in the game, Yadier Molina has also become a more than capable bat in the lineup. This year, he hit .319 and drove in 80 runs. Second baseman Matt Carpenter was a real surprise, though, as the rookie earned an All-Star berth, hitting .318, while scoring a major league-best 126 runs.