"He's a coach on the field. He sees what we're running, changes the offense and everything's quick," Eagles cornerback Brandon Boykin said of Manning. "He's not giving anybody time to get back there."
Philadelphia has 10 sacks on the season and defensive tackle Cedric Thornton had the only one in Denver.
Eagles veteran linebacker Trent Cole, who switched from defensive end under the new 3-4 scheme, has faced Manning's younger brother, Eli, many times and gave his take on what to expect Sunday.
"I know Eli is probably going to his brother and trying to get some tips, but every game is different, said Cole. "Every team goes in and makes their changes and does what they have to do to clean up their mistakes ... He'll do the same things. He'll do all of his checks. Eli is another one of the great quarterbacks in the NFL. He's an offensive coordinator on the field, too."
Manning has thrown an NFL-high nine interceptions, so that could work out in the Eagles' favor. However, the Eagles haven't intercepted a pass since taking two away from Redskins quarterback Robert Griffin III back in Week 1. Boykin and Cary Williams each have an interception for the Eagles, who have just two wins in the past 16 games dating back to last season.
The Eagles are last or near the bottom in most defensive categories. They are last in total yards allowed (446.8) and 31st in both points allowed (34.5) and passing yards given up (325.0). Philadelphia has allowed 121.8 rushing yards per game, but shouldn't be too concerned since the Giants are managing just 57.8 rushing yards a game (30th in NFL).
New York and Philadelphia split two meetings last season, but the Giants ended the season and Reid's tenure with the Eagles with a 42-7 drubbing at the Meadowlands last Dec. 30. The Giants are 81-73-2 all-time in this series, while Coughlin is 10-10 (0-2 playoffs) against the Eagles, who are 8-2 in the past 10 meetings between the teams.
WHAT TO WATCH FOR
Can New York's defense keep up with Eagles head coach Chip Kelly's break-neck tempo on offense? The Giants haven't been able to keep any style of offense from scoring and Sunday could turn out to be another long one.
Eagles quarterback Michael Vick has won 10 of his last 12 starts against the NFC East and has played well this season save a Thursday night loss to the Chiefs in Reid's return to Lincoln Financial Field. Vick has five touchdown passes to two interceptions this season and was 14-of-27 for 248 yards in the loss to the Broncos.
Vick talked about the Eagles' three-game losing streak and what it will take to turn the season around.
"We've been there, we know what it's like," Vick said. "The one thing we won't do is we won't go in the tank. Last year, you lost three games in a row and we just felt the world was coming to an end. You just have to pick yourself up, dust yourself off and keep going. Nothing's going to be given to you, you have to go out and earn it, that's why we're professionals and nobody's going to feel sorry for you. We understand that. We have opportunities to get out of this hole and it'll take going out there, playing on Sundays and winning."
The Eagles will have a good shot at winning if they can get LeSean McCoy off and running. The talented back leads the NFL with 468 rushing yards and 608 yards from scrimmage. He is averaging 152 scrimmage yards a game and has rushed for 100-plus yards in three of the past four games against the Giants, who have yielded 122.5 rushing yards per game this season.