Potentially back from injury could be wide receiver Kenny Britt, who sat out last week with a rib malady and is probable this time around. Britt had four catches and a touchdown when he last met Kansas City.
Should Fitzpatrick and his teammates emerge from the game error-free, they'd become the first team since 1967 to go five games from the beginning of the season without a turnover. The Titans and Chiefs share the NFL lead with a plus-9 turnover margin.
"It's discipline," Munchak said. "It's important to them. We work on it every day."
Tennessee is 13th in the league in scoring offense (24.5 PPG) and seventh in scoring defense (17.2 PPG).
WHAT TO WATCH FOR
Though they've won all four of their games and are the league's best team at keeping points off the board, the Chiefs have been far from impenetrable when it comes to the run.
Kansas City is just 24th in a 32-team league when it comes to total rush yards allowed (470) and just one slot ahead of the bottom when it comes to average yards per carry (5.4). Those starts have to perk up the ears of Titans running back Chris Johnson, who has yet to really assert himself through four games while averaging just 3.3 yards per carry and 69 yards per game.
On the other side, Bowe is big, physical and capable of taking over a game when he gets open consistently. Similar to Tennessee's Johnson, his statistics so far -- 13 catches, 148 yards, two TDs -- belie the impact he can have on a game. That said, his matchup with Titans cornerback Alterraun Verner is a difficult one because only eight-of-23 passes in Verner's direction this season have been completed.
Going into the regular season, this probably wasn't a game anyone -- outside of the head coaches -- had circled for any particular reason. But with a combined seven wins in eight outings, it's suddenly become one of the league's marquee events.
The Chiefs have been successful thus far thanks to Reid-like efficiency on offense and inspired play on defense. The Titans at home certainly represent a threat to the unbeaten run, but the loss of Locker is enough to tip the scales to K.C. at 5-0.
Sports Network predicted outcome: Chiefs 21, Titans 17