The Colts' Andrew Luck, who was the No. 1 overall selection in 2012, is 14-6 as a starter and matched Hall of Famer John Elway for the most wins in his first 20 starts by a QB selected No. 1 overall since the 1970 merger.
"He's such a mature kid and he understands the game," says Indianapolis head coach Chuck Pagano. "He prepares so well, and his focus is unbelievable. We know the physical talent is there. He's extremely intelligent. The great thing about Andrew is that he's unflappable. He's gotten better and he's his own critic."
PREDICTION: Colts 24, Seahawks 23
Baltimore (2-2) at Miami (3-1), Sunday, 1 p.m.
LINE: Dolphins by 3
THE SKINNY: A pair of AFC contenders coming off bad losses meet in South Beach as ex-Ravens linebacker Dannell Ellerbe gets a crack at his old teammates when reigning Baltimore visits the Dolphins.
Ellerbe, a keep cog in the Ravens' Super Bowl winning defense a year ago, left for Miami in free agency and leads the Dolphins with 38 tackles this season. He will be trying to short-circuit Joe Flacco, who is coming off a career- worst five-interception performance in a loss at Buffalo. In two career games versus Miami, though, Flacco has 498 passing yards with three TDs and no INTs with a 125.3 passer rating.
The Dolphins, who were eaten alive by New Orleans on Monday night, have won three straight at home.
PREDICTION: Ravens 24, Dolphins 21
Philadelphia (1-3) at New York Giants (0-4), Sunday, 1 p.m.
LINE: Giants by 2
THE SKINNY: The desperate Giants shoot for their first win against a Philadelphia team, which has dropped three straight. The Eagles, though, have won seven of their past nine against "Big Blue" and Michael Vick has won in 10 of his last 12 NFC East starts, compiling a 99.7 passer rating in those games. Philadelphia RB LeSean McCoy leads the NFL with 468 rushing yards and 608 scrimmage yards. For the Giants, QB Eli Manning is set to start his 140th consecutive game, the longest active streak by a signal caller in the NFL.
PREDICTION: Giants 27, Eagles 24
Jacksonville (0-4) at St. Louis (1-3), Sunday, 1 p.m.
LINE: Rams by 11 1/2
THE SKINNY: The woeful Jags could get a boost with the return of WR Justin Blackmon, who was suspended for the first four games for violating the league's substance abuse policy. Blackmon will team with Cecil Shorts to give embattled QB Blaine Gabbert, who has thrown for five TDs and no INTs in his last five road starts, a pair of solid options. The Rams, meanwhile, need a running game, having managed just 189 yards on the ground in four games.
PREDICTION: Rams 21, Jaguars 13
Kansas City (4-0) at Tennessee (3-1), Sunday, 1 p.m.
LINE: Chiefs by 3
THE SKINNY: The NFL's top two teams in turnover differential will meet at LP Field. Kansas City (plus-nine) has forced an AFC-best 12 takeaways and Tennessee (plus-nine) is the only team in the league without a turnover.
The Chiefs, who knocked off the New York Giants, 31-7, last weekend, are 4-0, the second team in NFL history to win its first four games after finishing the previous season with at least 14 losses (1980 Detroit).
"Awesome. It's great," Chiefs QB Alex Smith said of the team's start. "The entire focus was getting the first win. It's a week-to-week thing. You can't start looking down the line."
The Titans have won two in a row, including a 38-13 home victory over the New York Jets this past Sunday. Tennessee forced four turnovers in the victory, including two interceptions by cornerback Alterraun Verner and a forced fumble recovered in the end zone by defensive tackle Karl Klug.
"The work still isn't done," Verner said. "That's just the first quarter of the season. We have a lot more football to play."
The triumph was tempered a bit, however, by the right hip injury suffered by QB Jake Locker. A second MRI taken on the hip confirmed no major damage, but he will miss a few weeks of action.
"The area will need time to heal and strengthen, but he won't require surgery and he has already begun a rehab routine for both his hip and knee," the team said in a statement. "We certainly would expect him to miss a few weeks, but we are encouraged by the news."
PREDICTION: Chiefs 20, Titans 14
Carolina (1-2) at Arizona (2-2), Sunday, 4:05 p.m.
LINE: Panthers by 1 1/2
THE SKINNY: Carolina has won seven of its past eight against the Cardinals and QB Cam Newton made his NFL debut against Arizona, throwing for 422 pass yards and accounting for three TDs (two passing, one rushing), a coming out party that has helped Newton become the only player in league history with 8,000- plus passing yards (8,497), 40-plus passing TDs (46), 1,500- plus rushing yards (1,545) and 20-plus rush TDs (23) in his first 35 games.
Cards QB Carson Palmer has never lost to the Panthers (2-0) and the team should get a boost from the return of star inside linebacker Daryl Washington, who was suspended for the first four games after violating the league's substance abuse policy.
PREDICTION: Cardinals 20, Panthers 17
Denver (4-0) at Dallas (2-2), Sunday, 4:25 p.m.
LINE: Broncos by 7
THE SKINNY: The Broncos have won 15 consecutive regular-season games dating back to 2012, the longest active streak in the NFL, and they have won them all by at least seven points, the second-longest streak in NFL history (16 games, 1941-42 Chicago).
Denver star QB Peyton Manning already has 16 TD passes this season, the most ever through Week 4 of any season, while the team has scored an NFL-best 179 points, the second-highest total through the first four games in league history (183 points, 1966 Dallas.)
The Cowboys enter Week 5 leading the NFC East despite their 2-2 record and a loss in San Diego last weekend. Dallas QB Tony Romo connected with wide receiver Dez Bryant for two touchdowns in that game. Since the start of the 2012 season, Bryant leads the NFL with 16 receiving TDs.
"We want to be a contender," said Dallas linebacker Sean Lee, who had a 52- yard interception-return touchdown against the Chargers. "We want to be a team that can win week in and week out."
PREDICTION: Broncos 34, Cowboys 24
Houston (2-2) at San Francisco (2-2), Sunday, 8:30 p.m.
LINE: 49ers by 7
THE SKINNY: Houston will try to bounce back from its collapse against Seattle by taking it to the Seahawks' main rival in the NFC West, the 49ers. The Texans have won three straight on the road against NFC foes and QB Matt Schaub passed for 264 yards and two TDs in his lone start against San Francisco. Meanwhile, since becoming the 49ers starter, Colin Kaepernick is 5-1 at home with a 104.2 passer rating.
PREDICTION: 49ers 31, Texans 24
San Diego (2-2) at Oakland (1-3), Sunday, 11:35 p.m.
LINE: Chargers by 4
THE SKINNY: Sunday's Raiders-Chargers game was moved back seven hours due to the Oakland Athletics' playoff game on Saturday night. The high-powered Chargers are averaging 27 points per game in 2013, the second-best mark in the AFC, and revitalized QB Philip Rivers joined John Hadl (201) and Hall of Famer Dan Fouts (254) as the only players in franchise history with 200 TD passes when he tossed for three against Dallas last week.
The news wasn't all good for San Diego, however, as the team placed both wide receiver Malcom Floyd (neck) and outside linebacker Dwight Freeney (torn quadriceps) on injured reserve.
On the other side, the Raiders rank third in the AFC in rushing yards with 550 and could get Terrelle Pryor back from a concussion.
PREDICTION: Chargers 27, Raiders 14
New York Jets (2-2) at Atlanta (1-3), Monday, 8:40 p.m.
LINE: Falcons by 9 1/2
THE SKINNY: The 1-3 Falcons figure to be ornery when they face rookie QB Geno Smith and the New York Jets on "Monday Night Football." Atlanta is banged-up and coming off a rare home loss to New England. Falcons QB Matt Ryan, who passed for a career-high 421 yards last weekend, has won 10 of his past 13 starts against AFC teams and is 34-6 in home starts during his career.
The Jets figure to be without WRs Santonio Holmes (hamstring) and Stephen Hill (concussion), so the running game and Bilal Powell figure to be a key. Powell has 266 scrimmage yards in his past two games.
PREDICTION: Falcons 30, Jets 13