In the team's 38-17 win over Miami during Week 4, Brees completed 30-of-39 passes for 413 yards with four touchdowns with a 144.5 passer rating, tying two of his own NFL records with his ninth consecutive 300-yard passing game and his 10th in a row with 25-plus completions.
"He's playing at a really sharp level," Saints head coach Sean Payton said. "He did a good job with his progressions and protected the football. He's been outstanding."
New Orleans tight end Jimmy Graham is tied for the NFL lead with six receiving touchdowns -- the most ever by a tight end in September -- and his 458 receiving yards rank second in the league.
The Bears and their opportunistic defense are tied for first in the NFC North and will look to rebound from last week's loss at Detroit. Chicago has 10 interception-return touchdowns since the start of the 2012 season, the most in the NFL, and have scored three defensive touchdowns so this season.
PREDICTION: Saints 27, Bears 21
New England (4-0) at Cincinnati (2-2), Sunday, 1 p.m.
LINE: Bengals by 1 1/2
THE SKINNY: The Pats have won 13 of 14 regular-season games dating back to last season and will be aiming for their seventh consecutive road victory. They will have to do it without Pro-Bowl run-stuffer Vince Wilfork, who underwent a successful procedure Tuesday to repair a torn right Achilles' tendon he sustained in the team's win over Atlanta in Week 4.
Tom Brady, who is 4-0 in his career versus the Bengals, had thrown a TD in 52 consecutive games, just two off Drew Brees' NFL record, and "Tom Terrific" needs just two more TD throws to pass Fran Tarkenton (342) for the fourth most in NFL history.
Cincy is coming off a bad loss to AFC North Division-rival Cleveland, but has won five of its past six at home.
PREDICTION: Bengals 21, Patriots 20
Detroit (3-1) at Green Bay (1-2), Sunday, 1 p.m.
LINE: Packers by 7
THE SKINNY: The much-improved Lions could be running into an bye-week buzz saw in a well-rested Green Bay team. The Packers, who have won 14 of their last 15 against Detroit, had an extra week to prepare and that may be too much for the Lions to overcome.
Green Bay head coach Mike McCarthy is 13-1 in his career against the Motor City Kitties while QB Aaron Rodgers is a perfect 8-0, completing 169-of-246 (68.7 percent) for 2,239 yards with 18 TDs versus four interceptions
Lions RB Reggie Bush ranks second in the NFL with 144.3 scrimmage yards per game after running for 139 yards with a TD and adding 34 receiving yards against Chicago last weekend.
PREDICTION: Packers 31, Lions 24
Seattle (4-0) at Indianapolis (3-1), Sunday, 1 p.m.
LINE: Seahawks by 2 1/2
THE SKINNY: The Seahawks are 4-0 for the first time in franchise history after overcoming a 14-point fourth-quarter deficit to pull out a 23-20 overtime win at Houston in Week 4. The Colts, on the other hand, improved to 3-1 with a 37-3 win in Jacksonville and have won their past two games by a combined score of 64-10.
Taking center stage in this weekend's showdown will be each team's second-year starting quarterback.
Seattle's Russell Wilson, who was drafted in the third round (No. 75 overall) in 2012, has won 15 of his first 20 starts. He has passed for 3,905 yards with 32 touchdowns, 13 interceptions and a 99.1 passer rating in his career.
"He's done some pretty extraordinary things," said Seahawks head coach Pete Carroll about his young QB. "He can do special things. There are just not very many kids that are as well-prepared to take on the workload and the stress of this and all the pressure that comes with it."