Indianapolis (2-1) at Jacksonville (0-3), Sunday, 1 p.m.
LINE: Colts by 8
THE SKINNY: The musical chairs at quarterback continue in Jacksonville as Blaine Gabbert is expected back under center for the winless Jaguars. Gabbert, who missed the last two games after slicing open the back of his throwing hand, is 3-1 as a starter in his career against the Colts. Indy is coming off a huge win in San Francisco when Andrew Luck got the best of his old college coach at Stanford, Jim Harbaugh. In his young career, the former No. 1 overall pick is now 13-6 as the starter with the Colts and has seven rushing TDs over that span, the most by an AFC signal caller.
PREDICTION: Colts 23, Jags 9
New York Giants (0-3) at Kansas City (3-0), Sunday, 1 p.m.
LINE: Chiefs by 4 1/2
THE SKINNY: Before the season started, if you had said one of these teams would be undefeated and the other winless heading into their Week 4 matchup, almost everyone would have guessed the roles would be reversed. At 3-0 after Andy Reid returned to Philadelphia to beat the Eagles, the Chiefs have already surpassed their win total from the 2012 season (2-14). The Giants, on the other hand, are coming off their worst drubbing in the Tom Coughlin era, a 38-0 shutout loss to Carolina. Kansas City, which is shooting for a third straight win over an NFC East team, has an NFL best plus-9 turnover ratio this season and QB Alex Smith is 22-5-1 as a starter in his last 28 NFL games.
PREDICTION: Chiefs 21, Giants 17
Pittsburgh (0-3) at Minnesota (0-3), NFL International Series at London's Wembley Stadium, Sunday, 1 p.m.
LINE: Steelers by 1
THE SKINNY: If you were trying to sell American football across the pond, you probably wouldn't want a pair of 0-3 teams representing your product, but that's where the NFL finds itself. The Steelers look more primed to right the ship for at least one week here. Pittsburgh coach Mike Tomlin, who spent 2006 as the Vikings' defensive coordinator, is 17-8 against the NFC and his QB Ben Roethlisberger, the other "Big Ben" in the U.K. on Sunday, is 2-0 against Minnesota with a 91.9 passer rating and 24-9 overall against NFC teams.
PREDICTION: Steelers 27, Vikings 17
Arizona (1-2) at Tampa Bay (0-3), Sunday, 1 p.m.
LINE: Bucs by 3
THE SKINNY: Embattled Tampa Bay coach Greg Schiano, who has lost eight of his last nine games dating back to last season, has decided to bench veteran quarterback Josh Freeman in favor of rookie Mike Glennon. Freeman, although talented, has struggled with the Bucs off to an 0-3 start, completing just 45.7 percent of his passes with a dismal passer rating of 59.3, the worst in the NFL. Glennon was selected in the third round of April's draft after a standout career at North Carolina State. Arizona is hurting defensively, losing three linebackers to injury over the past week, starters Sam Acho (broken leg) and Lorenzo Alexander (foot) along with promising rookie Alex Okafor (torn biceps).
PREDICTION: Cardinals 17, Bucs 14
New York Jets (2-1) at Tennessee (2-1), Sunday, 4:05 p.m.
LINE: Titans by 3 1/2
THE SKINNY: Jets rookie QB Geno Smith passed for a career-high 331 yards with two TDs in a win over fellow freshman E.J. Manuel and Bills in Week 3. Now the West Virginia product will search for his first road win as a pro against Jake Locker and the Titans, who beat the Chargers for the first time in 21 years last week. Tennessee star running back Chris Johnson is averaging 109.5 rushing yards per game in his past two tries against New York and recorded a franchise- record 94-yard rush TD in his last game versus the Jets.
PREDICTION: Titans 20, Jets 14
Philadelphia (1-2) at Denver (3-0), Sunday, 4:25 p.m.
LINE: Broncos by 10 1/2
THE SKINNY: The Broncos have won 14 consecutive regular-season games dating back to 2012, the longest active streak in the NFL. Denver star QB Peyton Manning already has 12 TD passes this season, the most ever through Week 3 of any season. That's bad news for Philadelphia and its shaky pass defense, but the Eagles will have 10 days to prepare after playing the Thursday night game in Week 3, while Manning and Co. are in the midst a short week after throttling Oakland on "Monday Night Football."
PREDICTION: Broncos 40, Eagles 27
Washington (0-3) at Oakland (1-2), Sunday, 4:25 p.m.
LINE: Redskins by 3
THE SKINNY: Oakland could be behind the 8-ball against winless Washington after QB Terrelle Pryor suffered a concussion late in Monday night's 37-21 loss to the Broncos. Pryor had career highs in passing yards (281) and passer rating (112.4) before going down and leads NFL signal callers with 198 rushing yards in 2013. His backup, Matt Flynn, isn't nearly as dynamic. The Redskins are dealing with a historically poor defense early on as well as a QB, Robert Griffin III, still trying to find his way after suffering a serious knee injury in the playoffs a season ago.
PREDICTION: Redskins 17, Raiders 14
Dallas (2-1) at San Diego (1-2), Sunday, 4:25 p.m.
LINE: Cowboys by 2
THE SKINNY: The high-powered Chargers are averaging 26 points per game in 2013, the second-best mark in the AFC and revitalized QB Philip Rivers needs just three TD passes to join John Hadl (201) and Hall of Famer Dan Fouts (254) as the only players in franchise history with 200 or more. On the other side, the Cowboys may have finally found a formula for success, feed RB DeMarco Murray, who ran for 175 yards and a TD in a win over the Rams in Week 3. Dallas is 11-0 when Murray runs it 18 times or more in a game.
PREDICTION: Chargers 27, Cowboys 21
New England (3-0) at Atlanta (1-2), Sunday, 8:30 p.m.
LINE: Falcons by 1 1/2
THE SKINNY: "Football Night in America" will feature the two active quarterbacks with the best starting records when New England's Tom Brady (139-39, .781 winning percentage) and Atlanta's Matt Ryan (57-24, .704) meet.
Both clubs advanced to their respective conference's championship game a year ago, but the Falcons have stumbled out of the gate this time around.
Despite drastic changes at the skill positions around Brady, the Pats are 3-0 after a 23-3 win over Tampa Bay. Brady, who has now thrown a touchdown pass in 51 consecutive games, connected with rookie wide receiver Kenbrell Thompkins on two TD passes against the Bucs.
"I feel good, we're 3-0," Pats All-Pro nose tackle Vince Wilfork said. "You can't ask for anything better."
Actually 4-0 would be better, but the Falcons will be in desperation mode after a last-second defeat in Miami (27-23) in Week 3. At home, Atlanta has won 12 of its past 13 regular-season contests.
"I'm looking forward to having a big week," Falcons rookie cornerback Desmond Trufant said. "I can't wait. I know we're all looking forward to it. We've got a bad taste in our mouth right now, so we're just looking forward to getting back to grinding."
PREDICTION: Falcons 23, Patriots 17
Miami (3-0) at New Orleans (3-0), Monday, 8:40 p.m.
LINE: Saints by 6 1/2
THE SKINNY: A pair of undefeated teams will be showcased on "Monday Night Football" when the Saints host the Dolphins.
In Week 3, NOLA quarterback Drew Brees extended his streak of consecutive 300- yard passing games to eight, a game behind his own NFL record. Dynamic tight end Jimmy Graham was Brees' favorite target against Arizona with nine catches for 134 yards and two touchdowns, his second consecutive 100-yard performance.
"It's early but we're pleased with the start," Saints head coach Sean Payton said. "As there is every week, there are some things we want to look at and clean up and get corrected."
Miami defeated Atlanta in Week 3 with a come-from-behind, 27-23 victory when QB Ryan Tannehill threw a 1-yard touchdown pass to rookie tight end Dion Sims with 38 seconds remaining to give the Dolphins the victory.
"We are focusing on an excellent New Orleans team we have to get ready for," Dolphins head coach Joe Philbin said. "We have to do a lot of preparation and a little extra work to get familiar with their schemes and personnel."
Brees has won eight consecutive starts on "Monday Night Football" and has a 120.6 passer rating in those contests, completing 194-of-273 passes (71.1 percent) for 2,467 yards (308.4 per game) with 24 touchdowns and just five interceptions.
PREDICTION: Saints 30, Dolphins 20