This will be the 106th time the Raiders and Broncos have tangled with Oakland holding a solid 59-44-2 advantage.
WHAT TO WATCH FOR
If anyone can persevere without an elite left tackle it's Manning. The veteran is as smart as they come and has the quickest release since Dan Marino was in his prime with the Dolphins.
With Manning in the captain's chair the explosive Broncos lead the NFL with 90 points and are only the third team in the past 30 years to score 40-plus points in each of their first two games, joining the 2009 Saints and the 2001 Colts, who were also piloted by Manning.
Manning leads the league with a 131.0 passer rating and is the only player in NFL history with nine touchdown passes and no interceptions through the first two weeks of a season. Furthermore, the Broncos have beaten the last two Super Bowl champions by the combined score of 90-50.
If you cover Demaryius Thomas, Welker is going to get open. If you check both of those difference-makers, Eric Decker may jump up and bite you and if by some miracle, you lock down all the receivers, here comes Thomas, a 6-foot-5, 245-pound runaway locomotive in the open field.
The fact that Moreno solidified a somewhat shaky running game last week also adds to Oakland's worries on defense.
Through two games, the Raiders are tied atop the NFL with nine sacks. Of those, a league-high five are from defensive backs so defensive coordinator Jason Tarver is being very aggressive in an attempt to disrupt things.
"They've committed to some pressure," Fox said. "I think they're playing good team defense. They have had a lot of changes but right now they're playing good as a unit. That's the key for any team."
"They can get the sacks different ways," Manning added. "They have some good pass rushers yet they have multiple blitz packages. It's important to block your man and also know your assignment. I think communication will be pivotal against this defense."
Offensively, the Raiders currently boast the NFL's No. 1 rushing attack, averaging 198.5 yards per game. McFadden led the AFC entering Week 3 with 177 rushing yards and Pryor was third with 162 yards.
Right now it's Pryor's mobility that is causing the most problems for opposing defenses.
"It definitely opens up some things that we haven't seen thus far," Fox said when discussing Pryor's athleticism. "This is the first time we really have a real mobile guy. They're doing a terrific job utilizing him in the run game. Their standard run game or conventional run game is very good. They lead the league in rushing. So it will be a full test for our defense."
Denver is currently riding a 13-game regular-season win streak and can match the franchise record against Oakland with another on the plus-side, something that feels like a fait accompli.
"This will be the best team that we've faced and they're very talented, so we're going to have to do a good job of changing things up and mixing some things up, mixing some looks and be able to play a good, team game," Allen said.
Sports Network Predicted Outcome: Broncos 41, Raiders 17