Though there is still a long way to go, Smith's club will still look to avoid losing its first two games of the season for the first time since an 0-3 start to the 2007 campaign.
Atlanta started last season 8-0 before a loss in New Orleans.
The Falcons have won three of their past four meetings with the Rams since a seven-game series winning streak by St. Louis that spanned from 1999-2003. Atlanta also has won the past two encounters at home since the Rams' last road win in this series on Dec. 2, 2001.
This contest will also feature the top three picks of the 2008 draft. The Dolphins took tackle Jake Long first overall and he signed with the Rams this past offseason. St. Louis then selected defensive end Chris Long before the Falcons took Ryan.
WHAT TO WATCH FOR
While it won't be a return trip to St. Louis, it still figures to be an emotional game for Jackson, who faces off against the only other franchise he has been a part of.
Jackson entered the season as the league's active rushing leader having posted eight straight 1,000-yard seasons. He ripped off a 50-yard run in Sunday's loss, but was held to just 27 yards on the other 10 carries.
"I thought we were able to run the ball effectively at times and there were times when we could've done it better. I think he's a great addition to our offense and I think he shows what he's capable of doing in the scheme that we are running," Smith said of Jackson.
Both head coaches had differing opinions of their offensive lines following Week 1, with Bradford extending his streak of not getting sacked to three straight games dating back to last season.
The addition of left tackle Jake Long figured to strengthen the Rams' line and Bradford was able to complete 71.1 percent of his passes. That, despite the ground game managing just 67 yards on 24 carries. Daryl Richardson had the bulk of that yardage on 20 attempts.
"We kept the pocket clean for the most part. Sam was touched six times in the game and that was pretty good," said Fisher.
Rams running back Zac Stacy got just one carry versus the Cardinals and Isaiah Pead is set to return this weekend from his one-game suspension for violating the league's substance abuse policy. It is unknown if he will play in this game.
Ryan, meanwhile, was taken down three times by the Saints and hit several other times. Smith wants his offensive line to improve going forward.
"Well we have to protect the quarterback a lot better than we did today, but there's a lot of things we have to do better. (Ryan) was hit entirely too many times today and that's one of the things we have to correct," the coach said following the loss to the Saints.
Tackles Sam Baker and Lamar Holmes face a tough task this weekend in Rams front four, which is bookended by a pair of talented ends in Chris Long and Robert Quinn.
Quinn is coming off a huge game, having matched a career high with three sacks while also forcing two fumbles, one that was recovered by Long to set up a field goal.
"I've been saying he's is a top five -- eventually a top three pass rusher," Long said of Quinn. "He's as dangerous as anybody in the league. He's just going to continue to show it, and it's scary how good he can be."
St. Louis' secondary has plenty of Atlanta receivers to keep tabs on, including Jones, Gonzalez and Harry Douglas. Wide receiver Roddy White is usually on that list, but a high ankle sprain limited him to more of a decoy role versus the Saints and he was held to just two catches for 19 yards.