PREDICTION: Texans 30, Titans 14
Miami (1-0) at Indianapolis (1-0), Sunday, 1 p.m.
LINE: Colts by 3
THE SKINNY: Home is where Andrew Luck's heart is. The second-year star has won seven straight games as a starter in Lucas Oil Stadium and is 8-1 there overall. If things are close down the stretch, assume the "Luck" will be good for Indy, because the former Stanford star has had eight game-winning drives in the fourth quarter or overtime, the most by a QB in his first 17 games since the 1970 merger. Fellow second-year standout Ryan Tannehill passed for 290 yards with one TD and a 90.9 passer rating in a 23-20 loss to the Colts last season, the only time the Dolphins have lost when Tannehill records a 90- plus rating (6-1).
PREDICTION: Colts 24, Dolphins 20
Dallas (1-0) at Kansas City (1-0), Sunday, 1 p.m.
LINE: Chiefs by 3
THE SKINNY: Andy Reid's debut as Chiefs coach was pretty fruitful as Kansas City recorded a 28-2 victory at Jacksonville. QB Alex Smith, also making his Chiefs' debut, threw two touchdown passes and Jamaal Charles added a rushing score. The Cowboys, meanwhile, forced six turnovers in their Week 1 victory over the New York Giants. On offense, Tony Romo threw two touchdowns, both to tight end Jason Witten. Since 2011, Smith is 20-5-1 as starter with 32 TDs versus 10 INTs and a 95.0 passer rating.
PREDICTION: Chiefs 24, Cowboys 21
San Diego (0-1) at Philadelphia (1-0), Sunday, 1 p.m.
LINE: Eagles by 7 1/2
THE SKINNY: LeSean McCoy rushed for an NFL-best 184 yards and a TD last week on a career-high 31 carries. The Eagles are 11-1 when he totes it 20 times or more in game. The Chargers' Philip Rivers will attempt to bounce back from the colossal collapse against Houston on Monday and was 20-of-25 for 231 yards and two TDs in his only career start against Philly, a 31-23 Chargers win back in 2009.
PREDICTION: Eagles 27, Chargers 24
Detroit (1-0) at Arizona (0-1), Sunday, 4:05 p.m.
LINE: Lions by 2
THE SKINNY: Reggie Bush will try to build on his impressive debut performance with the Lions in the desert. Bush became the first player since Cid Edwards in 1972 with 90-plus rushing yards (90) and 100-plus receiving yards (101) in his first game with a new team. The Cardinals have won four straight over Detroit and QB Carson Palmer lit up the Lions in his last start against them while with the Oakland Raiders, completing 32-of-40 passes for 367 yards back in 2011.
PREDICTION: Cardinals 28, Lions 21
New Orleans (1-0) at Tampa Bay (0-1), Sunday, 4:05 p.m.
LINE: Saints by 3 1/2
THE SKINNY: Saints QB Drew Brees has won three in row as a starter against the Bucs, completing 80-of-112 passes for 942 yards with 10 TDs and just two picks over that span. Since joining New Orleans in 2006 the All-Pro leads the NFL with 33,928 passing yards and 246 TD throws. Embattled Tampa Bay signal caller Josh Freeman had a career-high 420 passing yards the last time the Saints were at Tampa.
PREDICTION: Saints 34, Bucs 24
Denver (1-0) at New York Giants (0-1), Sunday, 4:25 p.m.
LINE: Broncos by 4 1/2
THE SKINNY: The Manning brothers will meet at MetLife Stadium -- the home of Super Bowl XLVIII -- in what they hope is just the first of two meetings this season. This contest will mark the first time in NFL history that the opposing starting quarterbacks will have each thrown for at least 400 yards in the previous week.
Denver is coming off a 49-27 win over Baltimore, the largest margin of victory against a defending Super Bowl champion in a season opener. Peyton Manning completed 27-of-42 passes for 462 yards with an NFL-record-tying seven touchdowns and no interceptions for a 141.1 passer rating.
"It's fun to play quarterback when you have a lot of guys working hard and making a lot of plays for you," Manning said.
Eli Manning and the Giants will be attempting to rebound from a 36-31 defeat at Dallas. In that game, the younger Manning threw for 450 yards and four touchdowns, but the Giants turned the ball over six times.
"Now we have to look ahead to the Denver Broncos," said Giants safety Antrel Rolle. "We all know what Peyton Manning brings to the table. We just have to play our best football and continue to grow."
PREDICTION: Giants 30, Broncos 24
Jacksonville (0-1) at Oakland (0-1), Sunday, 4:25 p.m.
LINE: Raiders by 6
THE SKINNY: Perhaps the NFL's two worst teams meet in the Bay Area when the Jags and Raiders square off. Chad Henne takes over at QB for Jacksonville, which laid a 28-2 egg against Kansas City in its home opener last Sunday. Henne, who is in for the injured Blaine Gabbert, threw for 307 yards and two TDs in his last effort against Oakland back in 2010 when he was with the Dolphins. New Raiders starter Terrelle Pryor, who will be making his first career start at home, rushed for 112 yards last week in a setback at Indy, a franchise single-game record for a QB.
PREDICTION: Raiders 20, Jags 14
San Francisco (1-0) at Seattle (1-0), Sunday, 8:30 p.m.
LINE: Seahawks by 3
The first installment of the expected arms race atop the NFC West happens Sunday night in Seattle when the defending NFC champion 49ers visit the Seahawks.
The Niners opened the season by knocking off Green Bay, 34-28, behind Kaepernick and his new favorite target, veteran wide receiver Anquan Boldin, who played for the Super Bowl champion Ravens last season. Boldin had 13 catches for 208 yards against the Pack, while Kaepernick threw for a career- high 412 yards and three touchdowns.
"It was great to go out there and get this win," Kaepernick said. "You always want to win your opener; it sets the tone for the season."
The Seahawks, meanwhile, traveled to Carolina in Week 1 and defeated the Panthers, 12-7, behind second-year QB Russell Wilson, who passed for 320 yards and a touchdown.
"It's about overcoming adversity," said Seattle Pro Bowl cornerback Richard Sherman. "Getting this type of game early is going to help us throughout the season."
Last year, the Seahawks were 8-0 at home as Wilson became the first rookie in NFL history to win all eight home games. In those eight contests, Wilson threw for 17 touchdowns and only two interceptions for a 123.6 passer rating.
PREDICTION: Seahawks 23, 49ers 17
Pittsburgh (0-1) at Cincinnati (0-1), Monday, 8:40 p.m.
LINE: Bengals by 7
THE SKINNY: The Steelers lost far more than a game last week when Pro Bowl center Maurkice Pouncey, linebacker Larry Foote and running back LaRod Stephens-Howling all went down with season-ending injuries against Tennessee. Expecting Pittsburgh to continue its recent dominance over Cincinnati could be too much to ask. The Steelers have won 10 of their past 11 against the Bengals and coach Mike Tomlin is 7-1 on Monday nights, but Cincy QB Andy Dalton has nine TD passes versus just one pick over his previous four home starts.
PREDICTION: Bengals 21, Steelers 14