Jose Reyes saved the Marlins from being on the wrong end of history for the second time this season.

But his seventh-inning single with one out to break up Dodgers pitcher Chris Capuano’s bid for a no-hitter wasn’t enough to spare the Marlins from another frustrating defeat.

Reyes’ hit was the only significant blemish to a combined two-hitter by Capuano and reliever Jamey Wright that allowed the Dodgers to blank the Marlins 5-0 on Sunday afternoon before 28,388 at Marlins Park.

Capuano gave up the two hits in eight innings and struck out 10 after coming eight outs away from what would have been the Dodgers’ 24th no-hitter all-time and second against the Marlins (Ramon Martinez, 1995).

Reyes also saved the Marlins from being no-hit on Opening Day against the Cardinals when he also singled in the seventh inning to break up Kyle Lohse’s hitless effort.

The Marlins (52-63) suffered their 11th shutout loss of the season and fourth at home.

“We were looking for good pitches to hit, but [Capuano] pitched well and had good control,” Reyes said.

“You don’t want any pitcher to no-hit you, and the way our season’s going if we get no-hit, it would have been an embarrassment.”

Capuano’s performance overshadowed Marlins starter Wade LeBlanc’s best outing since being inserted into the starting rotation.

LeBlanc, who had not pitched more than 4 1/3 innings in his first two starts, lasted seven Sunday and gave up only one run on six hits. LeBlanc had no walks and struck out four.

“LeBlanc gave us what we wanted from him,” Marlins manager Ozzie Guillen said.

“This kid is taking a step forward, and hopefully his next start he pitches the same way.”

LeBlanc sharp

LeBlanc threw 102 pitches (73 for strikes) in his longest outing since Sept. 28 with the Padres. LeBlanc has a 1.76 ERA in three starts so far this season.

The only significant trouble he ran into came in the third inning when he loaded the bases with no outs on three consecutive singles by Capuano, Shane Victorino and Mark Ellis. LeBlanc struck out Matt Kemp, gave up the lone run on a sacrifice fly by Hanley Ramirez and got Andre Ethier to ground out.

“I just gave up one too many, and Capuano threw great and kept us off balance,” LeBlanc said. “Hanley laid off some pitches, and I feel like I let him get away and he drove in the run.

“For the most part, I minimized the damage, but the way Capuano was pitching, giving that one up was the game.”

The Marlins’ only other hit off Capuano was a soft fly ball hit by Nick Green that dropped a foot inside the right-field line for a one-out single in the eighth.

Capuano walked three batters but got out of trouble each time.

Austin Kearns drew two of those free passes, but Donovan Solano hit into a double play in the second, and Kearns was caught stealing in the fifth by former Marlins catcher Matt Treanor to end two potential scoring threats.

“Capuano had an unbelievable changeup that seemed to come out around 88 [mph], but it felt like he was throwing it at 100,” Reyes said.

“You have to give him credit.’’

Big weekend

Ramirez finished his homecoming weekend going 6 for 13 with five RBI. On Sunday, Ramirez went 2 for 4 with three RBI, and delivered the big hit off reliever Heath Bell in the top of the eighth.

Ramirez smacked a hard single to left with runners on second and third that allowed Mark Ellis and Matt Kemp to score to give Los Angeles a 3-0 lead. Bell exited after giving up an RBI single to Ethier on the next at-bat. The game-winning RBI was Ramirez’s major league-best 18th of the season.

“The game went from a good game to a very bad game in one inning,” Guillen said. “It’s fun to watch a 1-0 or 2-1 game because anything can happen. All of a sudden the game went south.”