It’s George Lopez, live, on HBO. The famed Chicano comedian debuts his comedy special from the LA’s Nokia Theater 10 p.m. Saturday. It’s called It’s Not Me: It’s You, and Lopez says the title is a nod to honesty.

“We live in a society that’s not very direct,’’ he says. “Like, on Twitter you get messages on how bad or untalented you are, but it’s nothing they would say to your face.”

To be sure, Lopez will not hold back his opinion.

Can you give us a hint of what you’ll be talking about up there?

There will be a little bit of Mitt Romney. His father [former Gov. of Michigan George W. Romney] was born in Mexico. So he suffers a little bit of what Obama suffers from, so I’ll be calling for Romney’s birth certificate. Me and Donald Trump.

You’ve met the president. How is he in person?

He only invites me to the White House when there’s Latino festivals. I want to go to there on a regular day [laughs]. I first met him when he was campaigning in 2008, and he still is a very decent man, and I respect him.

Who are some of your favorite comedians?

Louis CK is great. He’s been doing it awhile, and I like comedians who have tenure. With social media and YouTube and clips and things like that, it’s a sweet opportunity to not travel the road and go through the bumps and the bruises. He’s earned his stripes.

Are you big into social media yourself?

I have a pretty good following on Twitter, like a million and a half! That’s tremendous. People must ask, ‘How does George Lopez have that many followers?’ I’m asking myself the same thing.

Do you like the Internet in general? Do you use it to get material?

I’m dyslexic, so I like to write and doodle and stuff like that. The computer is a little structured for me. I keep a pad around and write on that. The Internet is an amazing thing, but it also has a lot of negativity to it. I’ve been studying a little bit of meditation, and Twitter and Facebook have no place in that.

What are some of the things you do in your down time?

I’m big into the unsolved murder mysteries. I’ll spend four hours watching those shows. You know, if you look at the psychology, it’s usually riveted in greed. Or you find out that the person you got involved with is not the person you think they are.

How do you enjoy doing standup?

The Nokia is pretty big. Like 6,500 [people]. I have to say bigger is better. Once you start getting the audience, it’s like a wave. Once you create the energy and stay on top of it, it’s a great ride, the best form of self-expression.

Does it feel like old hat by now or is it still fresh?

It’s never the same thing twice. You never know who’s going to show up. It could be 5,000 or you play to 100. It’s what drives you or drives you away. In preparing for this special I went into the clubs during the week and, wow, the amount of hecklers per people over served . . . . You’re there to work on your stuff, and they’re there to have a great time and apparently black out. I started in clubs, then got out. Going back you realize you’re just killing time until they sell drinks.